{"id":1436,"date":"2026-02-04T10:49:35","date_gmt":"2026-02-04T10:49:35","guid":{"rendered":"https:\/\/powerbuilding.pl\/weight-loss-ranking-of-the-best-supplements-hormones-thermogenics-and-experimental-substances\/"},"modified":"2026-03-06T18:42:16","modified_gmt":"2026-03-06T18:42:16","slug":"weight-loss-ranking-of-the-best-supplements-hormones-thermogenics-and-experimental-substances","status":"publish","type":"post","link":"https:\/\/powerbuilding.pl\/en\/weight-loss-ranking-of-the-best-supplements-hormones-thermogenics-and-experimental-substances\/","title":{"rendered":"Weight Loss: Ranking of the Best Supplements\/Hormones\/Thermogenics and Experimental Substances"},"content":{"rendered":"\n

List of effective substances – in the table, moderate effectiveness means it works; people simply often expect miracles. Supplementation is supplementation; there’s no point in weight loss without calorie reduction, no matter how many additives you take<\/strong>.<\/p>\n\n

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GLP-1 Peptides<\/th>Action<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
Retatrutide<\/a><\/strong><\/td>GLP-1\/GIP\/Glucagon \u2192 strong appetite suppression + accelerated metabolism<\/td>Very High<\/strong><\/td>Moderate<\/strong><\/strong>\u2013high<\/strong> – usually caused by too high a dose and lack of lifestyle changes, diet, hydration…<\/td><\/tr>
Sema + Capri<\/a><\/strong><\/td>GLP-1 + amylin analog \u2192 very strong appetite reduction<\/td>Very High<\/strong><\/td>… in studies, maximum doses were administered that people could tolerate to achieve maximum results and boast high effectiveness,…<\/td><\/tr>
Tirzepatide<\/strong><\/td>GLP-1\/GIP \u2192 strong appetite reduction<\/td>Very High<\/strong><\/td>… without changing their lifestyle and diet, so many people experienced quite unpleasant side effects during…<\/td><\/tr>
Semaglutide<\/a><\/strong><\/td>GLP-1 \u2192 appetite reduction<\/td>High<\/strong><\/td>… the use of each of these substances.Doctors then thoughtlessly prescribe doses straight from the leaflet.Dosage, diet, and hydration are crucial for minimizing side effects<\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
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Thermogenics<\/th>Compound<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
Clenbuterol<\/strong><\/td>Stimulates \u03b22 receptors in the body, which increases body temperature and metabolic rate, causing the body to burn more calories even at rest<\/td>Very<\/strong> High<\/strong><\/td>High<\/strong> Mainly dose-dependent. Clen initially causes strong thermogenesis, hand tremors, etc… the body quickly adapts to this.Clen still works, more gently but still very effectively.People increase doses if they don’t feel the jitters. In bodybuilding, old recommendations were to increase the dose to about 120mcg. These doses are strenuous for the heart (all of them, for that matter). Now I see more and more coaches recommending keeping a low dose of 20-40mcg throughout the entire period of use, sometimes even in combination with beta-blockers like Nebivol for maximum safety. Nebivol slightly reduces effectiveness, If you’re not preparing for Mr. Olympia, you probably have no reason to take more than 40mcg, <\/td><\/tr>
Salbutamol<\/strong><\/td>Works similarly to clenbuterol (also stimulates \u03b22 receptors), but for a shorter duration and less intensely; it accelerates metabolism and facilitates the release of fat from fat cells.<\/td>High<\/strong><\/td>Moderate<\/strong><\/strong><\/strong><\/strong><\/td><\/tr>
Mirabegron<\/strong>*Fun fact:<\/strong>Mirabegron relaxes the bladder, allowing it to hold more urine \u2013 if you wake up to pee 3-4 times a night, now it will be 1-2 times (just more at once)<\/td>Primarily activates \u03b23 receptors, which stimulate brown adipose tissue to produce heat, meaning burning energy instead of storing it.<\/td>Moderate<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/td>Moderate<\/strong><\/strong><\/strong><\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n
Stimulants<\/th>Action<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
ECA<\/strong>Ephedrine + Caffeine + Aspirin<\/strong>+Glutamine<\/strong> – protects the stomach from the effects of long-term aspirin use<\/td>A classic from years ago<\/strong>Ephedrine<\/strong> Stimulates the nervous system and \u03b2 receptors, increasing heart rate, body temperature, calorie burning rate, and facilitating fat release from fat cells. Reduces appetite. Caffeine<\/strong> \u2013 Blocks fatigue and stimulates the nervous system, causing the body to use more energy and more quickly tap into fat as a fuel source.Aspirin<\/strong> prolongs the action of Ephedrine.Often<\/strong> aspirin is replaced by yohimbineso-called ECY<\/strong>*Is anyone else as old as me and remembers supplements from Cyber<\/strong>? Thermal Pro<\/strong>?20 years ago we ate them like candy \ud83d\ude42<\/td>Very High<\/strong><\/td>Ephedrine<\/strong><\/strong> \u2013 can cause heart palpitations, elevated blood pressure, anxiety, insomnia, and an increased risk of cardiac arrhythmias.Aspirin<\/strong> \u2013 can irritate and damage the stomach lining (pain, heartburn, ulcers, bleeding), increase the risk of hemorrhage, and with prolonged use, strain the kidneys. *Do not use long-term without Glutamine<\/strong><\/td><\/tr>
Rauwolscine (\u03b1-yohimbine)<\/strong>Makes sense on an empty stomach before cardio<\/td>A more active form of yohimbine; works in the same way but more strongly and quickly, increasing fat mobilization from ‘stubborn’ areas (abdomen, thighs).<\/td>Noticeable<\/strong><\/strong><\/td>Similar to ephedrine but milder for most people<\/td><\/tr>
Yohimbine<\/strong><\/strong>Makes sense on an empty stomach before cardio<\/td>Blocks \u03b12 receptors in fat tissue, which normally inhibit fat burning, making it easier for the body to release fat for burning<\/td>Noticeable<\/strong><\/strong><\/strong><\/strong><\/td>Often causes anxiety, irritability, sweating, increased heart rate, and blood pressure spikes, especially on an empty stomach.<\/td><\/tr>
Synephrine<\/strong><\/td>Primarily stimulates \u03b23 receptors and slightly the nervous system, which increases calorie burning without as strong an effect on heart rate as ephedrine or clenbuterol.<\/td>Low<\/strong><\/strong><\/td>Low but <\/strong>can cause increased heart rate, blood pressure elevation, anxiety, and headaches, especially when combined with caffeine or other stimulants.<\/td><\/tr>
Caffeine<\/strong><\/td>Blocks fatigue and stimulates the nervous system, causing the body to use more energy and more quickly tap into fat as a fuel source<\/td>Moderate<\/strong><\/strong><\/td>Low but <\/strong>Can cause anxiety, sleep problems, hand tremors, stomach aches, and increased heart rate.<\/td><\/tr>
Stimulants in general<\/strong><\/td><\/td><\/td>Stimulants<\/strong> increase the burden on the heart and nervous system, which can lead to insomnia, anxiety, hypertension, and a risk of heart problems with overuse.Lack of sleep<\/strong> -> greater loss of muscle mass than fat mass.<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div><\/div>\n\n\n\n
Hormones<\/th>Mechanism<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
T3 (Triiodothyronine)<\/strong>Thyroid hormone<\/td>increases the metabolic rate of the entire body, forcing cells to burn energy faster.<\/td>High<\/strong><\/td>Moderate<\/strong>.Heart palpitations, excessive sweating, muscle mass loss, thyroid dysregulation with overuse.<\/td><\/tr>
HGH<\/a><\/strong> at night and fasted cardio<\/td>Increases lipolysis<\/strong>, the release of fatty acids from fat cells into the blood.Therefore, after a dose of HGH at night, more free fatty acids circulate in the blood in the morning<\/strong>, and fasted cardio promotes their utilization as fuel instead of being re-stored as fat.HGH in the morning before cardio makes less sense because lipolysis is not immediate. <\/td>Good<\/strong><\/td>Low<\/strong> at doses sufficient for lipolysis, such as 1-2IU.For most people, even 3-4IU rarely cause side effects.It is definitely recommended to increase doses gradually, never starting with 4-6IU.Side effects<\/strong> with too high a dose or too rapid an increase in dose include water retention and joint pain.<\/td><\/tr>
AOD-9604<\/a><\/strong> 30-45min before fasted cardio<\/td>A fragment of HGH responsible for lipolysis, without anabolic effects and side effects like those of HGH.<\/td>Moderate<\/strong><\/td>Low<\/strong><\/td><\/tr>
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Increased endurance<\/th>Mechanism<\/th>Effectiveness<\/th>Risk<\/th><\/tr><\/thead>
Cardarine (GW501516)<\/strong><\/td>activates the PPAR-\u03b4 receptor, increasing fat burning and aerobic capacity. It reduces reliance on glucose and glycogen<\/strong> as primary fuel, which translates to larger glycogen stores on low-carb diets, thus leading to better gym workouts.Significantly improves endurance. <\/td>Moderate<\/strong> or quite significant. Depends on the situation. e.g. if you’re at the end of a diet, calories are very low, and carbohydrates are scarce, Cardarine will greatly help with workouts, thus leading to a greater amount of calories burned, especially from fat.<\/td>Moderate<\/strong>.In animal models, it can cause cancer.There are probably no documented cases in humans, even though they consume it like candy.I would stick to a low dose of 10mg – this is not advice, just personal feelings.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Compound<\/th>Action<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
BAM15<\/strong>Mitochondrial Uncoupler.<\/td>Forces the body to burn more calories as heat.Other known uncouplers are DNP and Usnic Acid.<\/td>no human studies<\/strong><\/strong>; I haven’t tried it personally, and I don’t have enough data from others yet<\/td>no human studies, those who take it don’t report anything drastic.<\/strong>Certainly, the risk is not at all close to DNP from what we currently know.*Are you taking it? Write a comment <\/td><\/tr>
MOTS-C<\/strong><\/a>a mitochondrial peptide that improves insulin sensitivity and fat utilization as fuel.<\/td>Significantly increases energy levels <\/strong><\/td>Indirectly – more energy despite calorie reduction<\/strong>.For me, it’s high; you don’t feel tired on a diet.<\/td>Low<\/strong>\/none?<\/td><\/tr>
5-Amino-1MQ<\/strong><\/td>Inhibits the NNMT enzyme, which can increase metabolic rate and fat burning, because by blocking NNMT, the body better utilizes energy from fat instead of storing it in cells.<\/td>no human studies<\/strong>I’m currently testing it; it seems to help, but I haven’t tested it long enough yet.<\/td>Low<\/strong>\/none<\/td><\/tr>
Methylene Blue<\/strong>*it’s best not to combine all possible substances that improve mitochondrial function, as this can have negative effects.For me, MOTS-C is the best option.<\/td>Improves mitochondrial function and electron transport, increasing energy production in cells<\/td>Indirectly through higher energy levels.<\/strong><\/td>Nausea, headaches, urine discoloration, risk of interaction with serotonergic drugs<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Compound<\/th>Mechanism<\/th>Effectiveness<\/th>Risk<\/th><\/tr><\/thead>
SLU-PP<\/strong> 332<\/strong><\/td>an experimental ERR agonist that increases the number and activity of mitochondria, accelerating metabolism. This allows cells to more efficiently produce energy from fat and glucose, which can support fat burning and improve physical performance<\/td>Noticeably increases energy levels.<\/strong>I tested doses up to 400mg (mg, not mcg) daily.Ultimately, it seems that doses below 1mg give me the best effect. With newer data, it seems that more is not better in this case. We need to wait for more data,<\/strong>PS if anyone wants to experiment, I still have some 50mg tablets and 100mg capsules. <\/strong> <\/td>No data, I know from people that large doses can increase blood pressure.<\/strong>Doses of 250-750mcg seem safe and effective.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
Compound<\/th>Mechanism<\/th>Effectiveness<\/th>Side Effects<\/th><\/tr><\/thead>
L-Carnitine (injectable)<\/strong><\/td>Transports fatty acids to mitochondria, facilitating their burning during exercise<\/td>Noticeable at doses of 600mg daily.<\/strong><\/strong>At the beginning, it’s probably best to do a ‘loading’ phase, taking it with carbohydrates. Maybe I’ll write a separate article with the protocol<\/td>Low<\/strong><\/td><\/tr>
L-Carnitine (oral)<\/strong>+ garlic extract (Allicin), I would never take it without<\/td>same as above<\/td>Low<\/strong><\/td>Promotes the growth of bacteria responsible for TMA production, which is converted to TMAO in the liver (Increased risk of heart attack and stroke).Garlic extract (Allicin) inhibits TMA production.<\/td><\/tr><\/tbody><\/table><\/figure>\n<\/div><\/div>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

List of effective substances – in the table, moderate effectiveness means it works; people simply often expect miracles. Supplementation is supplementation; there’s no point in weight loss without calorie reduction, no matter how many additives you take. GLP-1 Peptides Action Effectiveness Side Effects Retatrutide GLP-1\/GIP\/Glucagon \u2192 strong appetite suppression + accelerated metabolism Very High Moderate\u2013high – usually caused by too high a dose and lack of lifestyle changes, diet, hydration… Sema + Capri GLP-1 + amylin analog \u2192 very strong…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[66,16,62],"tags":[],"class_list":["post-1436","post","type-post","status-publish","format-standard","hentry","category-weight-loss","category-bez-kategorii","category-supplementation-supplements"],"_links":{"self":[{"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/posts\/1436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/comments?post=1436"}],"version-history":[{"count":0,"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/posts\/1436\/revisions"}],"wp:attachment":[{"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/media?parent=1436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/categories?post=1436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/powerbuilding.pl\/en\/wp-json\/wp\/v2\/tags?post=1436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}